MUC6 CORPUS FREE DOWNLOAD

In addition to tethering the mucus to the epithelial surface, MUC1 is a sensor of the environment including microorganisms and it can be shed from the cell surface Mucin multilayers assembled through sugar-lectin interactions. A human annotator manually went through each candidate relation instance to decide 1 whether there is a relation between the two arguments and 2 whether there is an explicit sequence of words describing the relation held by ARG-1 and ARG Furthermore, TFF2 is also expressed in minor amounts in the immune and nervous systems. Other than as a lectin, TFF2 is probably also covalently bound via disulfide bridges to the cysteine-rich domains of MUC6 at least in the porcine gastric mucus This could explain the multiple and diverse biological effects of TFF2 [e. However, ultrastructural studies of the excretory flow of gastric glands clearly described the merging of zymogenic contents with MUC6 and the development of laminated mucus structures at the surface

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In vWF, this domain is responsible for dimeric N-to-N assembly between juxtaposed D3 domains via two homophilic inter-molecular disulfide bridges, i.

Click here to edit contents of this page. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Unless otherwise stated, the content of this page is licensed under Creative Commons Attribution-ShareAlike 3.

Message Understanding Conference (MUC) 6 - Linguistic Data Consortium

Spasmolytic polypeptide is a major antral peptide: There are numerous reports of a pH gradient across the gastric mucus barrier with near neutral pH at the mucosal surface 5084 Generally, folding and initial polymerization of mucins occur in the ER, which requires the protein disulfide isomerase AGR2 There are instances P, N with distinct juc6 int NYT dataset and corous P, N with 70 distinct descriptors.

Recent progress in paradoxical concanavalin A staining. From structure to function. For example, TFF2 increased dramatically the viscosity and elasticity of porcine gastric mucin solutions in vitro Regulated mucin secretion from airway epithelial cells.

Acta Crystallogr D Biol Crystallogr. Survival in hostile territory: Biosynthesis of gastrokine-2 in the human gastric mucosa: Molecular medicine of TFF-peptides: Similarly, we performed sentence splitting, tokenization and NER tagging, and took pairs of PER, PER entities occurring in the same sentence as a candidate relation instance.

Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection. Their role in the diagnosis and prognosis of gastric cancer.

Corpora - TimexPortal

Isolation and characterization of putative trefoil peptide receptors. Append content without editing the whole page source. Protection against acid and pepsin.

One possibility is that it may be rubbed off after food intake. Vicinal cysteines in the prosequence play a role in von Willebrand factor multimer assembly. However, there are indications that the binding characteristics of these peptides are different.

TFF2 also has a protective function against the progression of premalignant lesions in H. TFF2 plays a critical role in maintaining gastric mucosal integrity and appears to restrain tumorigenesis in the stomach.

Also the effects on gastric pH regulation 45 and proton permeation through gastric mucus fit well with a role of TFF2 for MUC6 assembly and stabilization of the mucus barrier.

Labeled by Dayne Freitag. The human stomach is also the host for a variety of non- H. Thickness and physical state in vivo.

Aspects of the biology of regeneration and repair in the human gastrointestinal tract. TailfordEmmanuelle H. References Publications referenced by this paper. Thus, similar to galectins, its lectin activity would perfectly enable TFF2 to form multivalent complexes and cross-linked lattices with a plethora of transmembrane glycoproteins and thus modulate different signal transduction processes.